Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →
Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →
Neuropathic pain is a complex and often life-disrupting condition that affects millions of people across the United States. Characterized by sensations like burning, stabbing, tingling, or electrical shock-like discomfort, this type of pain arises not from external injuries but from malfunctioning nerves. Whether caused by diabetes, shingles, chemotherapy, spinal cord injury, amputation, or post-surgical nerve damage, neuropathic pain stems from damaged or dysfunctional nerve fibers misfiring, sending exaggerated or even phantom signals to the brain.
Because neuropathic pain originates in the nervous system itself—rather than as a direct response to injury or inflammation—it often defies traditional treatment methods. Commonly used options like opioids, corticosteroids, anti-inflammatories, or even physical therapy may offer some relief, but they rarely address the root of the problem. At Tennessee Ketamine & Wellness Center in Franklin, TN, we offer a science-driven solution for individuals who have exhausted other options: IV ketamine infusion therapy, designed specifically to target the neurochemical pathways involved in chronic nerve pain. By acting on key pain circuits in the brain and spinal cord, ketamine offers the potential for lasting relief, improved functionality, and better quality of life—often within just days of starting treatment.
The persistent nature of neuropathic pain is closely linked to a process called central sensitization—a phenomenon where the central nervous system becomes hyper-responsive to stimuli. In this state, the brain and spinal cord not only amplify existing pain signals, but may also generate pain in the absence of any real threat. As a result, even light touch, warmth, or movement can feel unbearable.
Ketamine works by targeting this cycle at its source. It functions as an NMDA (N-methyl-D-aspartate) receptor antagonist, blocking the transmission of glutamate, the brain’s most abundant excitatory neurotransmitter. In people with neuropathic pain, excessive glutamate activity fuels overactive neurons, leading to heightened pain perception. Ketamine disrupts this pattern, calming down the nervous system and restoring balance in key pain-processing regions.
But ketamine’s benefits don’t stop there. In addition to reducing excitatory signaling, ketamine encourages neuroplasticity—the brain’s natural ability to reorganize itself and form new, healthier connections. This “resetting” effect can be especially helpful for individuals with long-standing nerve pain that hasn’t responded to more traditional medications like gabapentin or opioids. Patients treated at our Franklin clinic frequently report not only a reduction in the intensity and frequency of their nerve pain, but also improved sleep, decreased fatigue, and the ability to return to everyday activities—sometimes for the first time in years.
Unlike many standard treatments, ketamine doesn’t involve narcotics and doesn’t carry the risk of dependence, withdrawal, or long-term tolerance. It’s a valuable option for individuals who are unable—or unwilling—to rely on addictive pain medications.
One of the most exciting aspects of ketamine therapy is its fast onset of action. While traditional medications can take weeks to show any effect, ketamine often provides noticeable relief after just one or two infusions. For individuals living with constant pain, that speed matters.
Many patients experience symptom improvement that lasts well beyond the final infusion. Some report several weeks—or even months—of relief, making it easier to reduce or eliminate daily medications, avoid emergency care, and regain independence. Maintenance infusions can then be spaced out over time as needed.
At Tennessee Ketamine & Wellness Center, no two treatment protocols are exactly alike. We personalize every plan based on your unique condition, history, and symptoms. We adjust infusion dosage, session length, and scheduling to align with your body’s specific needs and response to therapy.
Your comfort and safety are our top priorities. All ketamine infusions are administered in quiet, private rooms, where our licensed medical staff closely monitors your vital signs, mental state, and overall experience throughout the session. We’re here to ensure each visit is therapeutic, supportive, and as effective as possible.
If chronic nerve pain has taken away your freedom, interfered with your relationships, or left you cycling through medications with little or no relief, know that you’re not alone—and that help is available. At Tennessee Ketamine & Wellness Center in Franklin, TN, we’re committed to providing advanced, personalized care that goes beyond temporary symptom suppression. Our ketamine infusion therapy is built on science, experience, and a belief that pain relief should be accessible and transformative.
Schedule your consultation today and learn how ketamine therapy may help you regain control, reduce pain, and restore the life you deserve. We’re here to walk beside you—every step of the way toward healing.
Conditions Treated
1909 Mallory Lane, Suite 300, Franklin, TN 37067