IV Ketamine Therapy in Franklin, TN

At Tennessee Ketamine & Wellness Center in Franklin, TN, we offer IV ketamine therapy as a modern, research-backed option for individuals struggling with treatment-resistant mood disorders and chronic pain conditions. For those who haven’t found lasting relief through traditional medications or therapy, IV ketamine may provide a new path forward—one grounded in neuroscience and administered with compassionate, medically supervised care.

What Is IV Ketamine Therapy?

IV ketamine therapy involves the administration of a low-dose ketamine solution through an intravenous infusion. Ketamine, originally developed and approved by the FDA as an anesthetic, has since been recognized for its powerful and fast-acting effects on mood and pain regulation—particularly in cases where other treatments have failed.

What makes IV infusion unique is its delivery method. By administering ketamine directly into the bloodstream, we ensure immediate and accurate dosing that bypasses the digestive system. This allows for rapid onset and higher bioavailability compared to oral or intranasal options. IV ketamine is an off-label treatment, meaning it is used outside its original FDA-approved indication, but it is guided by a growing body of clinical research and medical best practices.

What Conditions Can IV Ketamine Help Treat?

IV ketamine is most often recommended for individuals who haven’t responded to conventional therapies. At our clinic in Franklin, TN, we use ketamine infusions to support patients with the following conditions:

Depression

Major depressive disorder and treatment-resistant depression can leave individuals feeling hopeless, emotionally numb, and disconnected from everyday life. Many patients come to us after trying multiple antidepressants or years of therapy with little success. We use IV ketamine and SPRAVATO® to help patients experience meaningful symptom relief—often within days rather than weeks. These treatments work differently from SSRIs, targeting brain chemistry and neural pathways involved in mood regulation and emotional resilience.

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Post-Traumatic Stress Disorder (PTSD)

PTSD is more than just a reaction to trauma—it can be a long-term, life-disrupting condition that affects sleep, mood, memory, and the ability to function. Flashbacks, emotional numbness, hypervigilance, and persistent anxiety are common symptoms. Ketamine therapy has shown promising results in helping patients reduce trauma-related distress by enhancing neuroplasticity and interrupting maladaptive thought loops. For those who have not responded to traditional PTSD treatments, ketamine may offer a new direction toward healing.

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Anxiety Disorders

Persistent anxiety can take many forms—generalized worry, panic attacks, social avoidance—but the result is often the same: a reduced quality of life. For individuals whose anxiety hasn’t improved with conventional treatments, IV ketamine may provide relief. By acting on glutamate receptors in the brain, ketamine helps calm overactive circuits involved in fear and worry. Many patients report a sense of clarity and relief after just a few sessions, giving them space to re-engage with daily life and long-term goals.

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Obsessive-Compulsive Disorder (OCD)

OCD can create a cycle of intrusive thoughts and repetitive behaviors that are difficult to control. Standard treatments like SSRIs and CBT can help, but many patients don’t find complete relief. Ketamine has been shown to disrupt the rigid thought patterns at the root of OCD by resetting neural activity and promoting cognitive flexibility. We work closely with patients to evaluate their history, determine candidacy, and deliver infusions that align with their needs and goals.

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Alcohol Use Disorder (AUD)

Alcohol dependence is often compounded by emotional pain, depression, or trauma. For patients in recovery or those struggling with chronic relapse, ketamine can be a powerful adjunct to their care plan. Though not a standalone addiction treatment, IV ketamine has been shown to reduce cravings, lift mood, and support neurobiological healing during early recovery. We offer ketamine treatment as part of a comprehensive, medically supervised approach for patients seeking lasting change.

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Bipolar Disorder

Bipolar disorder causes intense shifts in mood, energy, and focus—ranging from deep depression to episodes of mania or hypomania. For those who haven’t found relief with traditional medications, ketamine offers a promising alternative. By targeting brain pathways involved in mood regulation, ketamine may help reduce depressive symptoms and promote emotional stability. Our team carefully evaluates each patient to determine if this treatment is a safe and effective option.

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Complex Regional Pain Syndrome (CRPS)

CRPS is one of the most severe and misunderstood pain conditions. Often triggered by injury or surgery, it causes intense, burning pain, skin changes, and hypersensitivity—sometimes spreading beyond the original site of injury. IV ketamine can help by interrupting the feedback loop between the injured area and the brain, calming the nervous system and reducing pain intensity.

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Neuropathy

Whether caused by diabetes, chemotherapy, surgery, or injury, neuropathic pain often feels like burning, tingling, or stabbing sensations. Standard medications may not touch this kind of pain. Ketamine works by calming overactive nerve activity, helping patients regain comfort, mobility, and sleep quality.

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Phantom Limb Pain

Even after a limb is gone, the brain can continue to generate intense pain sensations—sometimes for years. Phantom limb pain is not imagined; it’s neurological. Ketamine helps by recalibrating the brain’s sensory map and quieting the misfiring nerves that cause pain in a limb that is no longer there.

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Postherpetic Neuralgia

This lingering nerve pain after shingles can be severe, unrelenting, and resistant to conventional treatments. IV ketamine may reduce the sensitivity of affected nerves and help the central nervous system break free from the pain cycle.

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Trigeminal Neuralgia

Often described as one of the most painful conditions known to medicine, trigeminal neuralgia causes sharp, electric-shock-like pain in the face. Ketamine’s ability to modulate central nerve pathways offers potential relief where traditional medications or surgical procedures fall short.

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Headache and Facial Pain Syndromes

For patients with chronic migraines, cluster headaches, or facial neuralgia, pain can be constant and disabling. Ketamine has shown promise in reducing headache frequency, duration, and severity—especially in patients who haven’t responded to traditional interventions.

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Eligibility for IV ketamine treatment is determined on a case-by-case basis during a comprehensive evaluation. Every patient’s history, current symptoms, and medical profile are carefully reviewed before beginning treatment.

Why Patients Choose IV Ketamine

Traditional medications such as SSRIs and pain relievers often take weeks to work—and in many cases, they never fully alleviate symptoms. IV ketamine stands apart for its rapid action and its ability to engage the brain’s glutamate system, which plays a central role in both mood and pain regulation.

Here’s why many patients in Franklin choose IV ketamine therapy:

Fast-Acting Relief: Some patients report noticeable improvements within 24–48 hours.
Alternative to Opioids: Ketamine provides pain relief without the risks of addiction or tolerance associated with opioids.
Restoration of Hope: For those who have tried everything else, ketamine offers new possibilities when other treatments have failed.
Neuroplasticity Support: By promoting the growth of new synaptic connections, ketamine helps reset dysfunctional brain pathways.

What to Expect During an IV Infusion

From the moment you arrive at Tennessee Ketamine & Wellness Center, you’ll be in a welcoming, medically supervised environment designed to support both safety and peace of mind.

Here’s how a typical treatment experience unfolds:

Pre-Treatment Check-In: You’ll undergo a brief assessment to confirm you’re ready for the infusion. Vitals are taken, and you’ll settle into one of our quiet, private treatment rooms.
Infusion Session: A low-dose ketamine solution is delivered through an IV over approximately 40–60 minutes. You’ll remain awake but relaxed during the process.
Common Sensations: Many patients describe mild dissociation, a sense of detachment, or dreamlike awareness during treatment—all normal and typically short-lived.
Post-Treatment Monitoring: After the infusion, you’ll rest in your room while we continue to monitor your vitals and recovery. Once you’re cleared, a friend or family member will need to drive you home.

Safety and Side Effects

At Tennessee Ketamine & Wellness Center, your safety is our highest priority. Every infusion is administered by trained professionals under close supervision.

Common Side Effects:

Mild nausea
Temporary lightheadedness or drowsiness
Short-term dissociation or changes in perception

These effects typically resolve within one to two hours after the session. Because ketamine is used in precise, low doses under medical supervision, it does not carry the same risk profile as recreational or high-dose misuse.

We conduct a full medical screening before beginning treatment to ensure that IV ketamine is safe and appropriate for your specific needs.

Treatment Frequency and Duration

IV ketamine therapy is typically delivered in two phases: induction and maintenance.

Induction Phase:

6 infusions over 2–3 weeks

Designed to provide a strong initial response and symptom reduction

Maintenance Phase:

Booster infusions spaced out every 3–6 weeks (or as needed)

Customized based on your condition, symptom return, and personal goals

For chronic pain conditions, infusion protocols may vary slightly in frequency and duration compared to mood disorders. We adjust every treatment plan based on your response and overall progress.

Who May Be Eligible for IV Ketamine Therapy

IV ketamine is not the right solution for everyone, but it may be a fit for:

Adults diagnosed with treatment-resistant depression
Individuals with chronic neuropathic pain or complex mood disorders
Patients who have not responded adequately to standard therapies, including medications and psychotherapy

You may not be eligible if:

You are currently pregnant or breastfeeding
You have uncontrolled high blood pressure or significant cardiac conditions
You have a history of psychotic disorders or active substance misuse

All patients are carefully screened through a medical and psychiatric intake process to determine eligibility.

Take the First Step Toward Relief

You don’t have to continue suffering in silence. If depression, anxiety, PTSD, or chronic pain has disrupted your life—and traditional treatments haven’t worked—IV ketamine therapy may offer the relief you’ve been searching for.

Contact Tennessee Ketamine & Wellness Center in Franklin, TN today to schedule your initial consultation. Our caring and experienced team is here to answer your questions, guide your care, and support your recovery every step of the way.

FAQs About IV Ketamine Therapy

How soon will I feel results?

Some patients feel better within 24 to 48 hours of their first infusion. Others may require several treatments to notice a significant change.

Is IV ketamine covered by insurance?

Coverage varies. While ketamine therapy is off-label, some patients may qualify for partial reimbursement. Our team can help you understand your options.

Will I need to stop my current medications?

In most cases, you can continue your existing medications. However, we’ll review everything during your intake to ensure compatibility.

Can I drive after treatment?

No. You must arrange transportation after each session, as the medication can impair reflexes and awareness temporarily.

How long will the benefits last?

Results vary. Many patients experience several weeks of relief after a full course. Maintenance infusions help extend these benefits over time.

Schedule A Consultation

We know how busy life can be, so we offer the option of contacting you based on your preferences to discuss Ketamine Infusion Therapy. Please provide your information below and we will contact you in the timeframe that you choose.