Find Relief with SPRAVATO® Nasal Spray Therapy

For individuals battling treatment-resistant depression, finding a therapy that truly works can be an exhausting process. At Tennessee Ketamine & Wellness Center in Franklin, TN, we offer a powerful, FDA-approved option: SPRAVATO® (esketamine) nasal spray therapy. Developed for adults who haven’t experienced meaningful relief from traditional antidepressants, SPRAVATO® offers a new path forward with fast-acting results, all in a carefully monitored medical environment. If conventional medications have failed you, this innovative therapy may finally bring the relief you’ve been seeking.

What Is SPRAVATO®?

SPRAVATO® is a prescription nasal spray containing esketamine, a derivative of ketamine. It is the first and only FDA-approved ketamine-based treatment for treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts or behaviors.

Unlike standard oral antidepressants, which may take several weeks to begin working, SPRAVATO® often brings noticeable improvement within days. It is administered exclusively in certified treatment centers under direct medical supervision and is never dispensed for home use. Tennessee Ketamine & Wellness Center is a certified SPRAVATO® treatment provider, offering a structured and supportive environment for patients who qualify.

Who Is Eligible for SPRAVATO®?

SPRAVATO® may be appropriate for adults who:

Have tried two or more antidepressants without adequate relief
Are diagnosed with treatment-resistant depression
Experience major depressive disorder with suicidal ideation or behavior
Need an alternative to IV ketamine infusions due to medical or personal considerations

Before starting treatment, every patient undergoes a thorough medical and psychiatric evaluation to determine suitability. Our clinical team ensures that SPRAVATO® is a safe and appropriate option for each individual’s needs.

How SPRAVATO® Treatment Works

SPRAVATO® is administered intranasally under the supervision of a licensed healthcare provider in our Franklin, TN clinic. Patients self-administer the spray, but are closely monitored before, during, and after each dose to ensure safety and comfort.

Initial Phase:

Two treatments per week for the first four weeks
Each session lasts approximately two to three hours, including monitoring time

Maintenance Phase:

Weekly or biweekly sessions, depending on individual response
Treatment plans are adjusted based on symptom improvement and overall progress

During every appointment, patients rest in a private treatment room while our clinical team monitors vital signs and treatment response. Due to the nature of the medication, patients must arrange for transportation after each visit, as they are not permitted to drive for the rest of the day.

Benefits of SPRAVATO® for Depression

SPRAVATO® offers a number of unique advantages over traditional treatments:

Rapid onset of symptom relief, often within the first few treatments
Reduces suicidal ideation, which is critical for patients in crisis
Targets the glutamate system, unlike SSRIs or SNRIs
Backed by FDA approval for treatment-resistant depression and MDD with suicidality
Works in combination with oral antidepressants, rather than replacing them

Many patients who begin SPRAVATO® after years of frustration with other treatments experience meaningful improvements in mood, clarity, and overall functionality.

What to Expect at Tennessee Ketamine & Wellness Center

At our Franklin clinic, we offer a professional, supportive experience tailored to the needs of each patient. SPRAVATO® treatments take place in a calm, private setting designed to encourage healing and reduce stress.

Patients can expect:

One-on-one medical oversight during every session
Continuous monitoring of heart rate, blood pressure, and psychological response
Comfortable, quiet treatment rooms to promote a relaxed state
Clear communication and education throughout your care plan

Our dedicated team has specialized experience in administering ketamine-based therapies and is committed to providing the highest standard of care at every step.

Is SPRAVATO® Covered by Insurance?

Because SPRAVATO® is FDA-approved, it is covered under many insurance plans, including some private insurers and Medicare. Coverage can vary depending on your provider and policy, but our administrative team is here to help.

We assist with:

Insurance verification and benefits checks
Pre-authorizations and paperwork
Clear, upfront pricing for self-pay patients
Flexible payment plans when needed

You’ll have a chance to review all cost details before starting treatment so you can make informed decisions with confidence.

Frequently Asked Questions About SPRAVATO®

How soon will I notice a difference?

Some patients report relief within 24 to 48 hours of their first treatment. Others may see gradual improvement over the first few weeks.

Can I take SPRAVATO® at home?

No. SPRAVATO® must be administered in a certified clinical setting under medical supervision.

Will I need to stop taking my other medications?

In most cases, no. SPRAVATO® is intended to be used alongside an oral antidepressant. Your current medications will be reviewed during your consultation.

How long does each appointment take?

You’ll need to remain at the clinic for approximately two hours after each session for observation and safety monitoring.

Is SPRAVATO® safe?

SPRAVATO® is FDA-approved and well-tolerated by most patients. Common side effects include mild dissociation, nausea, dizziness, and drowsiness, all of which typically resolve within hours.

Take the First Step Toward Relief

If depression has left you feeling hopeless or stuck despite trying multiple medications, SPRAVATO® may offer the fast, effective relief you need. At Tennessee Ketamine & Wellness Center in Franklin, we provide trusted, medically supervised care to help you find your way forward.

Contact our team today to schedule a consultation and learn whether SPRAVATO® therapy is right for you.

Tennessee Ketamine & Wellness Center Franklin, TN
Specializing in advanced treatments for depression and mood disorders.
Now accepting new patients for SPRAVATO® therapy.

Schedule A Consultation

We know how busy life can be, so we offer the option of contacting you based on your preferences to discuss Ketamine Infusion Therapy. Please provide your information below and we will contact you in the timeframe that you choose.