Excited to announce the launch of SPRAVATO®..... Click Here to Learn More →
SPRAVATO® (esketamine) is a groundbreaking nasal spray approved by the FDA for adults struggling with two challenging types of depression:

Treatment-Resistant Depression (TRD): Designed for individuals who have not responded to at least two different antidepressants.

Major Depressive Disorder (MDD) with Acute Suicidal Ideation or Behavior: A rapid-acting option for individuals experiencing intense symptoms and an urgent need for stabilization.
Unlike traditional oral antidepressants that may take weeks to work, SPRAVATO® has been shown to deliver symptom relief in as little as 24 hours.
SPRAVATO® operates differently from standard treatments by acting on NMDA receptors in the brain. This novel approach helps reset neural pathways that contribute to depression. Administered in our certified treatment center at Tennessee Ketamine & Wellness Center, patients self-administer the nasal spray under clinical supervision and remain on-site for observation for a minimum of two hours to ensure safety.

Start with a paid phone consultation, with the cost applied toward your infusion if you move forward with treatment. If eligible, you'll meet with our mental health professionals for a full evaluation and medical history review. We’ll also verify insurance coverage to avoid surprises.

After approval, your SPRAVATO® sessions will be scheduled at our clinic. You’ll self-administer the spray in a calm, comfortable environment while monitored by our staff for at least two hours.

Treatment begins with an induction phase (typically two sessions weekly) and transitions to maintenance dosing. We customize frequency based on your individual progress and needs.

Our care team is with you every step of the way. We offer regular follow-ups, collaborate with your existing mental health providers, and continuously adapt your care plan.

Week 1-4
2 Treatments a Week

Week 5-8
1 Treatments a Week

Week 9+
1 Treatments a Week Every 1-2 Weeks
Response Rate:
Conventional antidepressant medications generally yield positive treatment responses in about 40% to 60% of patients. In contrast, clinical research on SPRAVATO® (esketamine) has reported response rates reaching up to 70% (Popova et al., 2019, American Journal of Psychiatry).
Onset of Therapeutic Effect:
Whereas standard antidepressants may require between four to six weeks before users begin to notice any significant improvement, esketamine (SPRAVATO®) has been associated with symptom relief in as little as 24 hours, according to clinical trial data (BMC Psychiatry, 2022).
Sustained Remission Rates:
In a clinical trial, 43.8% of individuals who continued treatment with Spravato alongside an oral antidepressant at the three-month mark had entered remission from major depressive episodes.

We follow only FDA-approved treatment protocols.

Our clinic spaces are designed to support mental wellness.

We engage your existing care team to ensure consistent and holistic support.

We work with your insurance and handle all necessary paperwork.
No. SPRAVATO® must be administered in a clinical setting under supervision.
Download our informational materials to learn more about SPRAVATO® and how it may benefit your recovery journey.
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RN & Clinical Manager
Trina Haag is a highly experienced and compassionate Registered Nurse with over 15 years of expertise in patient care and advocacy. Her diverse background includes roles as a Medical Assistant, Phlebotomist, and Registered Nurse specializing in ICU and perioperative care. In addition to her clinical skills, Trina has successfully managed medical offices, where she excelled in delivering exceptional customer service and personalized patient care.
Trina’s commitment to patient advocacy is evident through her involvement with the National Patient Advocacy Foundation, where she passionately supports patient rights and quality healthcare. Her dedication to individualized care ensures that every patient at TNKWC receives the highest level of compassionate and personalized treatment.
Outside of her professional life, Trina values time spent with her family, including her loving husband, her daughter who brings joy to her days, and their loyal furry friend.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][us_image image=”568″ style=”shadow-2″][us_separator][us_btn label=”Schedule A Consultation” link=”url:%2Fcontact%2F|title:Contact” width_type=”1″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]
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Dr. Rachel Rome is a board-certified anesthesiologist and interventional pain specialist with a deep expertise in regenerative medicine and palliative care. Her commitment to individualized patient care, innovative treatment approaches, and her prioritization of utilizing a holistic approach has made her a respected figure in the medical community.[/vc_column_text][vc_column_text]Witnessing the transformative impact of ketamine on patients suffering from depression and chronic pain, Dr. Rome pursued advanced training in ketamine administration. In November 2021, she founded Mindful Infusions of TN, a concierge ketamine and wellness clinic, where she served as Medical Director. In addition, she has had the privilege of serving the local community at several clinics including David Price Regenerative Medical Center, LifeLinc Pain, and Empatia Palliative Care.
Dr. Rome earned her undergraduate degree in biology from Christian Brothers University and her medical degree from the University of Tennessee College of Medicine in Memphis. She completed her residency in anesthesiology and a fellowship in pain management at the University of Virginia in Charlottesville. She is an active member of the American Society of Anesthesiologists and the American Society of Interventional Pain Physicians.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][us_image image=”599″ style=”shadow-2″][us_separator][us_btn label=”Schedule A Consultation” link=”url:%2Fcontact%2F|title:Contact” width_type=”1″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]
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Dr. Malchow served as an anesthesiologist for 25 years in the armed forces before retiring as a colonel in 2008. He then became an associate professor at Vanderbilt University Medical Center in Nashville, where he was the first Vanderbilt physician to offer intensive ketamine infusion therapy in 2014. In 2015, he established one of the few ketamine infusion centers (KIC) in the Veteran Health Administration and the only KIC in the U.S. specifically targeting opioid cessation/reduction.
He is an acknowledged U.S. expert on ketamine administration, having presented his extensive experience with ketamine in the veteran population at the American Society of Ketamine Physicians in 2018 and has given multiple lectures regarding the use of ketamine to national audiences in 2021. Dr. Malchow has published over 20 peer-reviewed journal articles and serves regularly on worldwide medical missions supporting those in need.
Dr. Malchow is honored to serve as the Medical Director for the Tennessee Ketamine & Wellness Center to provide compassionate and competent care for those suffering from depression, PTSD, OCD, chronic pain, and opioid dependence.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][us_image image=”162″ style=”shadow-2″][us_separator][us_btn label=”Dr. Malchow’s Full CV” link=”url:%2Fwp-content%2Fuploads%2F2021%2F06%2F03-2021-Malchow-CV.pdf|target:_blank” width_type=”full” icon=”fas|file-alt”][us_btn label=”Schedule A Consultation” link=”url:%2Fcontact%2F|title:Contact” width_type=”1″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]